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Rabbits and guinea pigs commonly present symptoms related to the urinary system. At home, the owner may notice urine collecting in the hair on the inside of the rear legs, a more pungent smell to the urine, the pet straining to urinate, or hematuria (bloody urine). After a proper physical exam and a thorough palpation of the urinary bladder, the veterinarian may identify bladder stones (a firm, oval hard mass in the bladder) or "bladder sludge" in rabbits (a bladder filled with a grainy, sand-like material). X-rays of the abdomen allow the veterinarian to identify the type of bladder disease and/or the number of stones.
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Collecting tissue samples for cytology or histopathology allow a pathologist to often give a diagnosis of the type of mass or tumor your pet has. Samples can be obtained by fine needle aspirate or biopsy, where a piece of the mass is cut out. Based on what the mass appears like under the microscope, the pathologist can often give a prognosis of how the tumor will behave.